COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation
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چکیده
منابع مشابه
TRANSLATIONAL PHYSIOLOGY Angiopoietin-1 enhances skeletal muscle regeneration in mice
Mahroo Mofarrahi, Joseph M. McClung, Christopher D. Kontos, Elaine C. Davis, Bassman Tappuni, Nicolay Moroz, Amy E. Pickett, Laurent Huck, Sharon Harel, Gawiyou Danialou,* and Sabah N. A. Hussain* Meakins-Christie Laboratories, Department of Medicine, McGill University, Montréal, Quebec, Canada; Department of Critical Care, McGill University Health Centre, Royal Victoria Hospital, Montréal, Que...
متن کاملAngiopoietin-1 enhances skeletal muscle regeneration in mice.
Activation of muscle progenitor cell myogenesis and endothelial cell angiogenesis is critical for the recovery of skeletal muscle from injury. Angiopoietin-1 (Ang-1), a ligand of Tie-2 receptors, enhances angiogenesis and skeletal muscle satellite cell survival; however, its role in skeletal muscle regeneration after injury is unknown. We assessed the effects of Ang-1 on fiber regeneration, myo...
متن کاملDesigned angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse
Despite the advent of oral phosphodiesterase-5 inhibitors, curative treatment for erectile dysfunction (ED) remains unavailable. Recently, the link between ED and cardiovascular disease was unveiled and the main etiology of ED was found to be vasculogenic. Therefore, neovascularization is a promising strategy for curing ED. Angiopoietin-1 (Ang1) is an angiogenic growth factor that promotes the ...
متن کاملCOMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice.
To test whether chronic enhanced blood flow alters insulin-stimulated glucose uptake, we measured skeletal muscle glucose uptake in chow-fed and high-fat-fed mice injected with adenovirus containing modified angiopoietin-1, COMP-Ang1, via euglycemic-hyperinsulinemic clamp. Blood flow rates and platelet endothelial cell adhesion molecule-1 positive endothelial cells in the hindlimb skeletal musc...
متن کاملN-cadherin expression during peripheral nerve regeneration
The addition of NT-3 (neurotrophin 3) or NT-4 to injured nerves improves their regeneration potential and may aid axon guidance. It is not well defined whether NTs (neurotrophins) influence other elements, such as the cell-adhesion molecules, which promote nerve guidance and regeneration. Using poly3-hydroxybutyrate conduits, we applied either NT-3 or NT-4 to axotomized rat sciatic nerves and m...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-30513-7